Concurrent IRF4 Rearrangements in a Patient with B Cell and T Cell Disorders
نویسندگان
چکیده
Abstract Introduction/Objective IRF4 is a regulatory protein which required at several stages of B and T cell development differentiation. Rearrangements the chromosomal region have been detected in various neoplasms including distinct entity WHO tumor classification for diffuse large lymphoma (DLBCL) with rearrangement another an rearranged subtype CD30-positive lymphoproliferative disorder, lymphomatoid papulosis (LyP). Methods/Case Report We present case 52-year-old man past medical history treated Hodgkin disease remission who now presents DLBCL tonsil as well cutaneous LyP, both demonstrate gene rearrangement. Immunohistochemical stains support morphologic diagnoses cases using fluorescence situ hybridization (FISH). Results (if Case Study enter NA) NA. Conclusion The detection translocation two separate lineages may result from one handful possible explanations that we explore. First, mutation multipotent hematopoietic progenitor give rise to common lymphoid progenitors pass on subsequent differentiated lymphocytes. Second, de novo mutations be occurring lines leading mature lesions. Finally, it lesions not truly positive rearrangement, but rather background cells skin or are aberration. This unique lesion same patient possess rare genetic implications our understanding such significant subsequently impact diagnosis therapy going forward.
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2022
ISSN: ['0002-9173', '1943-7722']
DOI: https://doi.org/10.1093/ajcp/aqac126.221